rearranged primary renal myoepithelial carcinoma: a diagnostic conundrum

rearranged primary renal myoepithelial carcinoma: a diagnostic conundrum

Blog Article

Primary renal myoepithelial carcinoma is an exceedingly rare Agitator Retaining Bolt neoplasm with an aggressive phenotype and Ewing sarcoma breakpoint region 1 (EWSR1) rearrangement in a small fraction of cases.In addition to its rarity, the diagnosis can be challenging for the pathologist due to morphologic heterogeneity, particularly on the biopsy specimen.At times, immunohistochemistry may be indecisive; therefore, molecular studies should be undertaken for clinching the diagnosis.We aim to illustrate a case of primary myoepithelial carcinoma of the kidney with EWSR1-rearrangement in a 67-year-old male patient who presented with right supraclavicular mass, which was clinically diagnosed as carcinoma of an unknown primary.

An elaborate immunohistochemical work-up aided by fluorescent in-situ hybridization allowed us to reach a conclusive diagnosis.This unusual case report advocates that one should be aware of the histological mimickers and Ski de fond - Equipement - Bottes - Classic begin with broad differential diagnoses alongside sporadic ones and then narrow them down with appropriate ancillary studies.